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pentobarbital will lower the extent or influence of solifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers could raise the metabolism of ifosfamide to its Livel